Metformin and glucose starvation decrease the migratory ability of hepatocellular carcinoma cells: targeting AMPK activation to control migration
نویسندگان
چکیده
منابع مشابه
Prognostic significance of AMPK activation and therapeutic effects of metformin in hepatocellular carcinoma.
PURPOSE The AMP-activated protein kinase (AMPK) serves as an energy sensor in eukaryotic cells and occupies a central role in linking metabolism and cancer development. However, the phosphorylation status of AMPK and its therapeutic value in human hepatocellular carcinoma (HCC) remain unclear. EXPERIMENTAL DESIGN The phosphorylation status of AMPK (Thr172) was determined by immunoblotting and...
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15 صفحه اولMetformin and Hepatocellular Carcinoma
There is ample evidence that type 2 diabetes is an independent risk factor for the development of various cancers including hepatocellular carcinoma (HCC). Metformin, a widely used antidiabetic agent, has been shown to have chemopreventive properties that may reduce the risk of cancer in diabetes. Here we summarize clinical and experimental data concerning the role of metformin in diabetes-asso...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2019
ISSN: 2045-2322
DOI: 10.1038/s41598-019-39556-w